Effects of repeated intra-silicone oil injections of methotrexate on proliferative vitreoretinopathy grade C: a multicenter randomized controlled trial
In this randomized controlled trial, we assessed the effects of three consecutive intra-silicone oil (SO) injections of methotrexate (MTX) on the outcomes of surgery for proliferative vitreoretinopathy grade C (PVR-C). Seventy-four eyes of 74 patients with PVR-C were included. Of these, 37 eyes were assigned to the MTX group and 37 eyes to the control group. Fourteen patients failed to comply with the 6-month follow-up period. All eyes underwent vitrectomy and SO injection. In the MTX group, 250 µg MTX was injected into the SO after surgery and at weeks 3 and 6 postoperatively. The primary outcome was the retinal reattachment rate at 6 months. The secondary outcomes included limited PVR recurrence and adverse events. Retinal reattachment was achieved in 22 eyes (73.3%) in the MTX group and 23 eyes (76.7%) in the control group (difference: -3.4%, 95% CI: -25.2-18.5%). Limited PVR recurrence was observed in one eye (4.5%) in the MTX group versus nine eyes (39.1%) in the control group at 6 months (P = 0.01). No adverse effects were observed. Adjunctive treatment with three consecutive applications of intra-SO MTX did not reveal a significant effect on the retinal re-detachment rate but could statistically significantly reduce limited PVR recurrence.Trial registration: http//ClinicalTrials.gov NCT04482543, 22/07/2020.
Authors
- Mehrdad Mohammadpour (ORCID: https://orcid.org/0000-0002-9383-6362)
- Masoud Mirghorbani (ORCID: https://orcid.org/0000-0003-4295-2563)
- Khalil Ghasemi Falavarjani (ORCID: https://orcid.org/0000-0001-5221-1844)
- Hamid Ahmadieh (ORCID: https://orcid.org/0000-0002-8139-2661)
- Alireza Ramezani (ORCID: https://orcid.org/0000-0002-1925-1251)
- Hamid Riazi‐Esfahani (ORCID: https://orcid.org/0000-0003-2277-398X)
- Sahba Fekri (ORCID: https://orcid.org/0000-0002-7388-6725)
- Homayoun Nikkhah (ORCID: https://orcid.org/0000-0002-2414-4661)
- Sahar Mirzaei (ORCID: https://orcid.org/0000-0001-7474-5492)
- Mehdi Yaseri (ORCID: https://orcid.org/0000-0002-4066-873X)
- Nazanin Ebrahimiadib (ORCID: https://orcid.org/0000-0002-2058-9225)
- Pasha Anvari (ORCID: https://orcid.org/0000-0002-3765-4206)
- Hamid Safi (ORCID: https://orcid.org/0000-0002-4479-6149)
- Bahareh Kheiri (ORCID: https://orcid.org/0000-0001-9448-8104)
- Firouze Hatami (ORCID: https://orcid.org/0000-0003-0450-0961)
- Kaveh Fadakar (ORCID: https://orcid.org/0000-0001-5940-7655)
- Narges Hassanpoor (ORCID: https://orcid.org/0000-0001-8296-0918)
- Saeed Karimi (ORCID: https://orcid.org/0000-0002-3231-8414)
- Zahra Khorrami (ORCID: https://orcid.org/0000-0003-0590-4650)
- Sare Safi (ORCID: https://orcid.org/0000-0002-5860-6908)
- Ramin Nourinia (ORCID: https://orcid.org/0000-0002-2630-1069)
- Mojtaba Abrishami (ORCID: https://orcid.org/0000-0003-2001-7929)
- Nasser Shoeibi (ORCID: https://orcid.org/0000-0003-3544-0105)
- Fatemeh Abdi (ORCID: https://orcid.org/0000-0002-0280-2969)
- Siamak Moradian (ORCID: https://orcid.org/0000-0002-5328-7565)
- Anoushiravan Rahimi
- Mohammad Hossein Jabbarpoor Bonyadi
- Elias Khalili Pour
- Maryam Hosseini
- Mohammad Reza Ansari Astaneh
- Niloufar Mohammadbagheri
Institutions
- Iran University of Medical Sciences (IR)
- Tabriz University of Medical Sciences (IR)
- Mashhad University of Medical Sciences (IR)
- Noor Eye Hospital (IR)
- Research Institute for Endocrine Sciences (IR)
- Kowsar Hospital (IR)
- Farabi Hospital (IR)
- Imam Hossein Hospital (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1038/s41598-024-79708-1
- Citations
- 6
- Primary Topic
- Retinal and Macular Surgery
- Type
- article
- Field-Weighted Citation Impact
- 2.43
Funders
- Shahid Beheshti University of Medical Sciences