Chemical quantification of N-acyl alanine methyl ester (NAME) production and impact on temporal gene expression patterns in Roseovarius tolerans EL-164
Our findings support previous studies suggesting an ecological role for C16:1-NAME as antibiotic, by proving that NAME concentrations in batch cultures were higher than the minimal inhibitory concentrations against Maribacter sp. 62 - 1 (Flavobacteriia) and Skeletonema costatum CCMP 1332 (Coscinodiscophyceae) reported in the literature. Our study further exemplified the broad application range of dose-dependent testing and highlighted the different biological activities of NAMEs and AHLs.
Authors
- Jörn Petersen
- Janina Leinberger (ORCID: https://orcid.org/0000-0003-0319-056X)
- Thorsten Brinkhoff (ORCID: https://orcid.org/0000-0003-3917-6882)
- Diana Koteska (ORCID: https://orcid.org/0000-0001-9266-4848)
- Sahana Shivaramu (ORCID: https://orcid.org/0000-0003-4037-8051)
- Judith Boldt (ORCID: https://orcid.org/0000-0002-4598-634X)
- Stefan Schulz (ORCID: https://orcid.org/0000-0002-4810-324X)
- Jürgen Tomasch (ORCID: https://orcid.org/0000-0002-3914-2781)
Institutions
- Carl von Ossietzky Universität Oldenburg (DE)
- German Center for Infection Research (DE)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures (DE)
- Technische Universität Braunschweig (DE)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1186/s12866-024-03624-7
- Primary Topic
- Microbial Community Ecology and Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Carl von Ossietzky Universität Oldenburg
- Deutsche Forschungsgemeinschaft