Association of Coagulation Factor XI Level With Cardiovascular Events and Cardiac Function in Community-Dwelling Adults: From ARIC and CHS
Decreased FXI level is associated with greater incidence of HF, especially in older adults. It is also associated with prevalent AF, worse diastolic function, worse LA function, and greater LA size. More research is needed to assess potential unwanted effects of FXI inhibition on the risk of cardiovascular events and cardiac function.
Authors
- Álvaro Alonso (ORCID: https://orcid.org/0000-0002-2225-8323)
- Susan R. Heckbert (ORCID: https://orcid.org/0000-0002-7100-512X)
- Jeremy Van’t Hof (ORCID: https://orcid.org/0000-0002-9982-3685)
- Anne Eaton (ORCID: https://orcid.org/0000-0001-5900-9745)
- Amil M. Shah (ORCID: https://orcid.org/0000-0003-1056-4451)
- Yuekai Ji
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Riccardo Maria Inciardi (ORCID: https://orcid.org/0000-0003-4846-8529)
- Paulo H. M. Chaves (ORCID: https://orcid.org/0000-0001-8013-7928)
- Peter Ganz (ORCID: https://orcid.org/0000-0002-0437-8882)
- Faye L. Norby (ORCID: https://orcid.org/0000-0002-1975-0405)
- Michael J. Zhang (ORCID: https://orcid.org/0000-0003-2537-2831)
- Sanaz Sedaghat (ORCID: https://orcid.org/0000-0002-8296-1811)
- Lin Y. Chen (ORCID: https://orcid.org/0000-0002-0700-814X)
- Wendy Wang (ORCID: https://orcid.org/0000-0001-6025-0173)
Institutions
- Brigham and Women's Hospital (US)
- University of Minnesota (US)
- Emory University (US)
- University of California, San Francisco (US)
- Florida International University (US)
- University of Washington (US)
- Southwestern Medical Center (US)
- Surgical Specialties (Canada) (CA)
- Minneapolis Heart Institute Foundation (US)
- University of Minnesota Medical Center (US)
- Surgical Specialties (United States) (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Circulation
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1161/circulationaha.124.070278
- Citations
- 14
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 6.13