Renal Proximal Tubule Cell-Specific Megalin Deletion Does Not Affect Atherosclerosis But Induces Tubulointerstitial Nephritis in Mice Fed a Western Diet
PTC-specific megalin deletion does not affect atherosclerosis but leads to tubulointerstitial nephritis in mice fed a Western diet, with severe pathologies in male mice.
Authors
- Jessica J. Moorleghen (ORCID: https://orcid.org/0000-0002-2556-6719)
- Deborah A. Howatt (ORCID: https://orcid.org/0000-0002-0078-092X)
- Masayoshi Kukida (ORCID: https://orcid.org/0000-0002-8393-9333)
- Hong Lü (ORCID: https://orcid.org/0000-0002-0577-2558)
- Yuriko Katsumata (ORCID: https://orcid.org/0000-0002-0188-8094)
- Adam E. Mullick (ORCID: https://orcid.org/0000-0003-4600-961X)
- Naofumi Amioka (ORCID: https://orcid.org/0000-0002-5732-1951)
- Motoko Yanagita (ORCID: https://orcid.org/0000-0002-0339-9008)
- Ruben M. Sandoval (ORCID: https://orcid.org/0000-0002-3660-2092)
- Hisashi Sawada (ORCID: https://orcid.org/0000-0003-0017-6236)
- Kenneth W. Dunn (ORCID: https://orcid.org/0000-0003-4245-496X)
- Alan Daugherty (ORCID: https://orcid.org/0000-0003-2093-3775)
- Michael Franklin (ORCID: https://orcid.org/0000-0003-4993-0164)
- Liyuan Zhu (ORCID: https://orcid.org/0000-0003-1702-1118)
- Michelle M. Martinez Irizarry (ORCID: https://orcid.org/0000-0001-5995-9281)
Institutions
- MACOM (United States) (US)
- University of Kentucky (US)
- Kyoto University (JP)
- Ionis Pharmaceuticals (United States) (US)
- School of Advanced Study (GB)
- Cancer Research And Biostatistics (US)
- Institute on Aging (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1161/atvbaha.124.321366
- Citations
- 1
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- American Heart Association
- University of Kentucky
- Japan Agency for Medical Research and Development
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- Core Research for Evolutional Science and Technology