Andexanet Alfa–Associated Heparin Resistance in Cardiac Surgery: Mechanism and In Vitro Perspectives
Andexanet causes heparin resistance due to redistribution of UFH-bound AT. If andexanet cannot be avoided before heparinization and direct thrombin inhibitors are undesirable, our in vitro study suggests excess UFH should be considered as a potential strategy before AT supplementation.
Authors
- Bruce A. Sullenger (ORCID: https://orcid.org/0000-0002-5113-5541)
- Lei Ke (ORCID: https://orcid.org/0009-0002-7441-0697)
- Haixiang Yu (ORCID: https://orcid.org/0000-0002-1100-9882)
- James W. Frederiksen (ORCID: https://orcid.org/0000-0001-9246-0108)
- Charlene V. Chabata (ORCID: https://orcid.org/0000-0001-5626-6906)
- Prakash A. Patel
- Nabil K. Thalji (ORCID: https://orcid.org/0000-0001-8041-3304)
Institutions
- Duke University (US)
- Jefferson Hospital (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1161/atvbaha.124.321650
- Citations
- 4
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- University of Pennsylvania
- National Institutes of Health
- Perelman School of Medicine, University of Pennsylvania