The Role of Sex in the Effects of Smoking and Nicotine on Cardiovascular Function, Atherosclerosis, and Inflammation
The purpose of this study was to fill the existing literature gap through assessment of the differential sex effects of CS and nicotine on vascular function and atherosclerosis to identify sex-specific risk factors. We show sex-specific differences in endothelial function, plaque, inflammation, and extracellular matrix (ECM) regulators with exposure to CS and nicotine, which underscore the importance of assessing sex in tobacco and nicotine exposure studies. This study also shows the negative effect of oral nicotine administration as many oral dissolvable nicotine products, such as pouches and gum, are becoming increasingly popular among adolescents and young adults.
Authors
- Leila Khalili (ORCID: https://orcid.org/0000-0003-2272-5179)
- Stephen P. Chelko (ORCID: https://orcid.org/0000-0003-1675-5945)
- Gloria Salazar (ORCID: https://orcid.org/0000-0002-6239-7942)
- Vladimir Ukhanov (ORCID: https://orcid.org/0000-0001-9501-0145)
- Justin D. La Favor (ORCID: https://orcid.org/0000-0002-0845-3421)
- Michelle S. Parvatiyar (ORCID: https://orcid.org/0000-0002-9416-0069)
- Ann M. Centner (ORCID: https://orcid.org/0000-0002-9742-5165)
- Tooyib A. Azeez (ORCID: https://orcid.org/0000-0002-8101-2112)
- Orlando Laitano (ORCID: https://orcid.org/0000-0003-2768-1427)
- Abigail Cullen (ORCID: https://orcid.org/0000-0002-0375-9712)
- Riley Deitado
- Hyun Seok Hwang (ORCID: https://orcid.org/0000-0001-6777-3073)
- Stephanie Hill
Institutions
- Florida State University (US)
- Florida Department of Health (US)
- University of Oregon (US)
- University of Florida (US)
Publication Details
- Journal
- Nicotine & Tobacco Research
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1093/ntr/ntae274
- Citations
- 4
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Florida Department of Health