Patterns of C1-Inhibitor Plasma Levels and Kinin–Kallikrein System Activation in Relation to COVID-19 Severity
Our study's findings on the consumption of C1-INH and the activation of the KKS in the less severe stages of COVID-19 but not in the critical stage suggest a potential role for C1-INH in containing disease severity. These results underscore the importance of C1-INH in the early phases of the disease and its potential implications in COVID-19 progression and/or long-term effects.
Authors
- Chiara Suffritti (ORCID: https://orcid.org/0000-0002-8872-8842)
- Chiara Cogliati (ORCID: https://orcid.org/0000-0003-2980-6158)
- Sonia Caccia (ORCID: https://orcid.org/0000-0003-0829-5379)
- Agostino Riva (ORCID: https://orcid.org/0000-0003-3171-3049)
- Luca Gusso
- Silvia Berra (ORCID: https://orcid.org/0000-0003-1151-7040)
- Antonio Gidaro (ORCID: https://orcid.org/0000-0002-5379-1091)
- Andrea Zanichelli (ORCID: https://orcid.org/0000-0002-7512-4644)
- Debora Parolin (ORCID: https://orcid.org/0000-0002-1853-6554)
- Andrea Folcia (ORCID: https://orcid.org/0009-0006-1105-7338)
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Luigi Sacco Hospital (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- IRCCS Policlinico San Donato (IT)
- IRCCS Ospedale San Raffaele (IT)
- Azienda Ospedaliera Fatebenefratelli e Oftalmico (IT)
Publication Details
- Journal
- Life
- Published
- 2024-11-21
- DOI
- https://doi.org/10.3390/life14121525
- Citations
- 1
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.44
Funders
- Università degli Studi di Milano