Water-enabled <i>α</i>-C(sp<sup>3</sup>)–H amination <i>via</i> [1,6]-hydride transfer: green access to diazepino[6,5,4-<i>cd</i>]indoles
Water-enabled α -C(sp 3 )–H amination of 4-dialkylamino-indole-3-carbaldehydes with primary amines was developed for green synthesis of diazepino[6,5,4- cd ]indoles via cascade aldimine condensation/[1,6]-hydride transfer/cyclization.
Authors
- Tiesheng Shi (ORCID: https://orcid.org/0000-0002-0767-6324)
- Xiao‐De An (ORCID: https://orcid.org/0000-0002-4774-6083)
- Jian Xiao (ORCID: https://orcid.org/0000-0003-4272-6865)
- Houchen Wang (ORCID: https://orcid.org/0000-0002-9825-8661)
- Yao‐Bin Shen (ORCID: https://orcid.org/0000-0001-9987-7045)
- Bin Qiu (ORCID: https://orcid.org/0009-0002-1554-138X)
- Xiaolin Wang (ORCID: https://orcid.org/0000-0002-2399-7646)
- Qian-Hao Zhuang
Institutions
- Qingdao Agricultural University (CN)
- Zaozhuang University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1039/d4qo01761g
- Citations
- 12
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province