Echocardiographic Effects of Tiletamine-zolazepam and Ketamine-diazepam in Dogs Undergoing Ovariohysterectomy

Background: Echocardiography is ultrasound of heart. In order to promote reduction in mortality rates due to anaesthesia, it is essential to understand the potential depressant effects of anaesthetic drugs on the cardiovascular system, so that anaesthetic procedures are conducted in the best possible way. Cardiac monitoring during surgery offers rapid and safe information about the alterations that may appear during the surgical procedure that can affect cardiac functions. Methods: The present study was undertaken to evaluate the echocardiographic effects of Tiletamine-zolazepam and Ketamine-diazepam anaesthetic combination in twelve healthy female dogs for ovariohysterectomy. These twelve dogs were randomly allotted to two equal groups irrespective of age, breed and body weight. Dogs were anaesthetized with Tiletamine-zolazepam (7.5 mg/kg, IV) in group 1 and Ketamine (5.0 mg/kg, IV)-Diazepam (0.5 mg/kg, IV) in group II. Atropine sulphate (0.04 mg/kg IM) followed by butorphanol (0.2 mg/kg IM) after 10 minutes was used as preanaesthetic drugs. Echocardiographic indices were recorded at different time intervals during the study period. Result: Non-significant changes were found in both systolic and diastolic functions. Thus, present findings suggested that Tiletamine-Zolazepam and Ketamine-Diazepam anaesthetic combinations provided good cardiovascular stability in dogs undergoing ovariohysterectomy.