Effect of zoledronic acid on muscle metabolism in mice with osteoporosis combined with sarcopenia
Zoledronic acid can reduce muscle loss and damage by upregulating the mRNA expression of Wnt and PI3K and the protein expression of β-catenin and AKT.Our results provide a novel basis for the development of drugs for the treatment of osteoporosis combined with sarcopenia.
Authors
- Jie Gu (ORCID: https://orcid.org/0000-0003-2104-9367)
- Yuanlin Xu (ORCID: https://orcid.org/0000-0003-0742-9945)
- Ming Xu (ORCID: https://orcid.org/0000-0001-7974-0658)
- Xuchao Shi
- Bo Dai (ORCID: https://orcid.org/0000-0001-9827-3581)
- Weilong Li (ORCID: https://orcid.org/0000-0001-9448-7953)
- Jian Guo (ORCID: https://orcid.org/0000-0002-5954-7356)
Institutions
- University of Nottingham Ningbo China (CN)
- Ningbo No.6 Hospital (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1186/s12891-024-08054-0
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Ningbo University