A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67

<b>Background and Clinical Significance:</b> Abnormal uterine bleeding during the postmenopausal years is a pathological sign that may be due to simultaneous intrauterine and ovarian pathology. Granulosa cell tumours of the ovary are malignant neoplasms producing oestradiol, which leads to the abnormal proliferation of the endometrium, precancerous lesions, and endometrial carcinoma type I. <b>Case Presentation:</b> The authors present a clinical case of a 67-year-old woman with postmenopausal bleeding who underwent a total abdominal hysterectomy with bilateral adnexectomy, pelvic lymphadenectomy, and partial omentectomy. The histopathological examination showed a granulosa cell adult-type ovarian tumour and a malignant endometrial polyp with atypical hyperplasia of the endometrium. <b>Conclusions:</b> The immunohistochemical analysis of the malignant endometrial polyp confirmed the expression of oestrogen, progesterone receptors, and the biomarker Ki-67.

Authors

Institutions

Publication Details

Journal
Reports — Medical Cases Images and Videos
Published
2024-11-20
DOI
https://doi.org/10.3390/reports7040103
Primary Topic
Endometrial and Cervical Cancer Treatments
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67

Gita Yamakova-Vladova, E Uchikova, Eleonora Hristova-Atanasova, Kamen Yamakov et al.
Reports — Medical Cases Images and Videos
Endometrial and Cervical Cancer Treatments
article

A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67

Gita Yamakova-Vladova, E Uchikova, Eleonora Hristova-Atanasova, Kamen Yamakov, Maria Koleva-Ivanova, Veselin Belovezhdov, Krum Vladov
article en

Abstract

<b>Background and Clinical Significance:</b> Abnormal uterine bleeding during the postmenopausal years is a pathological sign that may be due to simultaneous intrauterine and ovarian pathology. Granulosa cell tumours of the ovary are malignant neoplasms producing oestradiol, which leads to the abnormal proliferation of the endometrium, precancerous lesions, and endometrial carcinoma type I. <b>Case Presentation:</b> The authors present a clinical case of a 67-year-old woman with postmenopausal bleeding who underwent a total abdominal hysterectomy with bilateral adnexectomy, pelvic lymphadenectomy, and partial omentectomy. The histopathological examination showed a granulosa cell adult-type ovarian tumour and a malignant endometrial polyp with atypical hyperplasia of the endometrium. <b>Conclusions:</b> The immunohistochemical analysis of the malignant endometrial polyp confirmed the expression of oestrogen, progesterone receptors, and the biomarker Ki-67.

Reports — Medical Cases Images and VideosVol. 7(4)
Medical University Plovdiv (BG)
Good health and well-being
Openalex Percentile: Top 67%
Endometrial and Cervical Cancer Treatments
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.