Stereoselective Total Synthesis of Natural Decanolides Bellidisin C and Pinolidoxin
A divergent total synthesis of bioactive, naturally occurring decanolides, pinolidoxin and bellidisin C, was accomplished by taking advantage of chiral templates <i>L</i>-ribose and <i>L</i>-malic acid. In particular, bellidisin C, which is the first total synthesis so far, was achieved through a cascade reaction of reductive elimination and nucleophilic addition in a one-pot process and a sodium-alkoxide-promoted intramolecular lactonization as the key steps.
Authors
- Yuanfang Liu (ORCID: https://orcid.org/0000-0002-5058-7685)
- Pengpeng Nie
- Jun Liu (ORCID: https://orcid.org/0000-0003-1487-0069)
- Jingjing Bi (ORCID: https://orcid.org/0000-0002-3842-0954)
- Yuguo Du (ORCID: https://orcid.org/0000-0002-2081-9668)
- Minhao Chen
Institutions
- Chinese Academy of Sciences (CN)
- Xinyang Agriculture and Forestry University (CN)
- Research Center for Eco-Environmental Sciences (CN)
- University of Chinese Academy of Sciences (CN)
- Henan Normal University (CN)
Publication Details
- Journal
- Molecules
- Published
- 2024-11-21
- DOI
- https://doi.org/10.3390/molecules29235500
- Primary Topic
- Synthetic Organic Chemistry Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China