Effect of XBB.1.5-adapted booster vaccination on the imprinting of SARS-CoV-2 immunity
In the present study, Pušnik et al. investigated whether the XBB.1.5-adapted booster can overcome the persistent imprinting of SARS-CoV-2 immunity by wild-type based vaccines. The findings demonstrate increased plasma neutralization against the homologous variant following the booster vaccination. Formation of de novo humoral response against the mutated epitopes of XBB.1.5 variant's surface proteins was observed in 3/20 individuals. The booster vaccination had no significant effect on T-cell response.
Authors
- Antonia Büning
- Werner O. Monzon-Posadas
- A Dubiel (ORCID: https://orcid.org/0000-0002-2743-5122)
- Jernej Pušnik (ORCID: https://orcid.org/0000-0002-5987-8606)
- Maximilian Baum
- Hendrik Streeck (ORCID: https://orcid.org/0000-0002-0335-6390)
- Emmanuil Osypchuk
- Paulina Fehring
- Tobias Klant
Institutions
- University Hospital Bonn (DE)
- German Center for Infection Research (DE)
Publication Details
- Journal
- npj Vaccines
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1038/s41541-024-01023-7
- Citations
- 5
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.95