Biological validation of peak‐width of skeletonized mean diffusivity as a VCID biomarker: The MarkVCID Consortium
Peak-width of skeletonized mean diffusivity (PSMD) is a novel small vessel disease neuroimaging biomarker. A prior instrumental validation study demonstrated that PSMD is a robust biomarker. This biological validation study shows that high PSMD relates to worse cognition. PSMD explains cognitive function above and beyond white matter hyperintensities. Future clinical validation will assess PSMD as a vascular contribution to cognitive impairment and dementia biomarker in clinical trials.
Authors
- Vilmundur Guðnason (ORCID: https://orcid.org/0000-0001-5696-0084)
- Charles DeCarli
- Brian T. Gold (ORCID: https://orcid.org/0000-0002-6958-7095)
- Alison M. Luckey (ORCID: https://orcid.org/0000-0002-1294-4696)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Christopher E. Bauer (ORCID: https://orcid.org/0000-0002-9697-4744)
- Adam M. Staffaroni (ORCID: https://orcid.org/0000-0002-3903-9805)
- Monica Goss
- Marilyn Albert (ORCID: https://orcid.org/0000-0002-8167-8985)
- Lara Stables
- Mohamad Habes
- Lars Forsberg
- Baljeet Singh (ORCID: https://orcid.org/0000-0002-8029-8577)
- Arvind Caprihan (ORCID: https://orcid.org/0000-0002-4810-359X)
- Laura J. Hillmer
- Chen‐Pin Wang
- Elyas Fadaee
- Haykel Snoussi (ORCID: https://orcid.org/0000-0001-8852-1115)
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Djass Mbangdadji
- Pauline Maillard (ORCID: https://orcid.org/0000-0003-3516-6345)
- Gary A. Rosenberg (ORCID: https://orcid.org/0000-0001-7426-7064)
- Kristin Schwab (ORCID: https://orcid.org/0000-0001-5723-9109)
- Steven Mark Greenberg (ORCID: https://orcid.org/0000-0003-1792-8887)
- Danny J.J. Wang (ORCID: https://orcid.org/0000-0002-0840-7062)
- Hector Trevino (ORCID: https://orcid.org/0009-0008-8067-3681)
- Herpreet Singh (ORCID: https://orcid.org/0000-0003-3797-7301)
- Thomas H. Mosley (ORCID: https://orcid.org/0000-0003-3343-1352)
- Saptaparni Ghosh (ORCID: https://orcid.org/0009-0009-6280-1624)
- Angel Gabriel Velarde Dediós
- Zhiguang Li (ORCID: https://orcid.org/0000-0003-2474-3485)
- Myriam Fornage
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-1206-404X)
- Claudia L. Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
- Lenore J. Launer
- Rebecca Bernal
- Hanzhang Lu
- Karl Helmer
- Jayandra J. Himali
- Alexa S. Beiser
Institutions
- Boston University (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- Boston Children's Hospital (US)
- National Institutes of Health (US)
- Mind Research Network (US)
- Harvard University (US)
- University of Kentucky (US)
- Johns Hopkins University (US)
- University of Iceland (IS)
- The University of Texas at San Antonio Health Science Center (US)
- University of New Mexico (US)
- Illinois Institute of Technology (US)
- Johns Hopkins Medicine (US)
- University of Mississippi Medical Center (US)
- Massachusetts General Hospital (US)
- Institute for Neurodegenerative Disorders (US)
- Brown Foundation (US)
- Institute on Aging (US)
- National Institute on Aging (US)
- Icelandic Heart Association (IS)
- University of California, Davis (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1002/alz.14345
- Citations
- 4
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- National Institute of Neurological Disorders and Stroke