Porphyromonas gingivalis-derived lipopolysaccharide promotes mesangial cell fibrosis via transforming growth factor-beta1/Smad signaling pathway in high glucose
Under HG conditions, <i>Pg</i>LPS may aggravate fibrosis in mesangial cells via the TGF-β1/Smad signaling pathway, leading to nephrosclerotic modifications. The presented study may support the association between periodontitis and chronic kidney disease, mediated by hyperglycemia.
Authors
- Risako Mikami (ORCID: https://orcid.org/0000-0003-1398-0450)
- Eri Sakaniwa
- Hiromi Kominato (ORCID: https://orcid.org/0009-0004-4685-157X)
- Masahiro Hakariya (ORCID: https://orcid.org/0000-0002-1717-0087)
- Mari Sugimoto
- Daisuke Kido (ORCID: https://orcid.org/0009-0002-8798-2707)
- Shu Takemura
- Akira Mima (ORCID: https://orcid.org/0000-0002-1250-7437)
- Natsumi Saito (ORCID: https://orcid.org/0000-0002-3313-7316)
- Koji Mizutani (ORCID: https://orcid.org/0000-0002-1610-7430)
- Takanori Iwata (ORCID: https://orcid.org/0000-0002-5461-7298)
- Keita Nakagawa (ORCID: https://orcid.org/0009-0005-6569-9080)
- A. Sugiyama (ORCID: https://orcid.org/0000-0003-0155-3726)
Institutions
- Tokyo Medical and Dental University (JP)
- Tokyo Medical and Dental University Hospital (JP)
- Osaka University of Pharmaceutical Sciences (JP)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1016/j.jds.2024.10.029
- Citations
- 3
- Primary Topic
- Esophageal and GI Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Science and Technology Agency
- JST-Mirai Program