6,8-Dibromo-11H-indeno[1,2-b]quinolin-11-one
We report the synthesis of the new compound 6,8-dibromo-11H-indeno[1,2-b]quinolin-11-one, which presents an important type of nitrogen-containing heterocycles and is a useful intermediate product in organic synthesis. The structure of the compound was confirmed by the single crystal X-ray diffraction. Molecular docking analysis revealed that 6,8-dibromo-11H-indeno[1,2-b]quinolin-11-one may effectively intercalate with DNA. The synthesized indenoquinoline derivative thus represents a promising lead compound for developing targeted anticancer and anti-inflammatory drugs.
Authors
- Аndrei S. Potapov (ORCID: https://orcid.org/0000-0003-2360-7473)
- Anastasia R. Kovrizhina (ORCID: https://orcid.org/0000-0002-9316-0964)
- Dmitry I. Pavlov (ORCID: https://orcid.org/0000-0002-5996-8062)
- Аndrei I. Khlebnikov (ORCID: https://orcid.org/0000-0002-3022-4510)
- Dauren Tolegen
Institutions
- National Research Tomsk State University (RU)
- Tomsk Polytechnic University (RU)
- Nikolaev Institute of Inorganic Chemistry (RU)
Publication Details
- Journal
- Molbank
- Published
- 2024-11-21
- DOI
- https://doi.org/10.3390/m1922
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation