6,8-Dibromo-11H-indeno[1,2-b]quinolin-11-one

We report the synthesis of the new compound 6,8-dibromo-11H-indeno[1,2-b]quinolin-11-one, which presents an important type of nitrogen-containing heterocycles and is a useful intermediate product in organic synthesis. The structure of the compound was confirmed by the single crystal X-ray diffraction. Molecular docking analysis revealed that 6,8-dibromo-11H-indeno[1,2-b]quinolin-11-one may effectively intercalate with DNA. The synthesized indenoquinoline derivative thus represents a promising lead compound for developing targeted anticancer and anti-inflammatory drugs.

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Publication Details

Journal
Molbank
Published
2024-11-21
DOI
https://doi.org/10.3390/m1922
Primary Topic
Bioactive Compounds and Antitumor Agents
Type
article
Field-Weighted Citation Impact
0.00

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article

6,8-Dibromo-11H-indeno[1,2-b]quinolin-11-one

Аndrei S. Potapov, Anastasia R. Kovrizhina, Dmitry I. Pavlov, Аndrei I. Khlebnikov et al.
Molbank
Bioactive Compounds and Antitumor Agents
article

6,8-Dibromo-11H-indeno[1,2-b]quinolin-11-one

Аndrei S. Potapov, Anastasia R. Kovrizhina, Dmitry I. Pavlov, Аndrei I. Khlebnikov, Dauren Tolegen
article en

Abstract

We report the synthesis of the new compound 6,8-dibromo-11H-indeno[1,2-b]quinolin-11-one, which presents an important type of nitrogen-containing heterocycles and is a useful intermediate product in organic synthesis. The structure of the compound was confirmed by the single crystal X-ray diffraction. Molecular docking analysis revealed that 6,8-dibromo-11H-indeno[1,2-b]quinolin-11-one may effectively intercalate with DNA. The synthesized indenoquinoline derivative thus represents a promising lead compound for developing targeted anticancer and anti-inflammatory drugs.

MolbankVol. 2024(4)
National Research Tomsk State University (RU), Tomsk Polytechnic University (RU), Nikolaev Institute of Inorganic Chemistry (RU)
Russian Science Foundation
Good health and well-being
Openalex Percentile: Top 79%
Bioactive Compounds and Antitumor Agents
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