<scp><i>MFRP</i></scp>, <scp><i>PRSS56</i></scp>, and <scp><i>MYRF</i></scp> account for 60.5% of a Chinese cohort with nanophthalmos
MFRP, PRSS56, and MYRF account for the majority of genetic causes of NO. MFRP-related NO patients tend to exhibit a strong predisposition to complications. Null variants in MFRP and PRSS56 may increase susceptibility to clinical complications. This study provides insights into the genetic landscape and clinical characteristics of NO. These findings will lead to a better understanding of the mechanisms underlying nanophthalmos and other diseases associated with eye development.
Authors
- Ren‐Juan Shen
- Zi‐Bing Jin (ORCID: https://orcid.org/0000-0003-0515-698X)
- Jing Tao (ORCID: https://orcid.org/0009-0008-4351-7380)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
Publication Details
- Journal
- Clinical and Experimental Ophthalmology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1111/ceo.14465
- Citations
- 3
- Primary Topic
- Ocular Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.65
Funders
- National Natural Science Foundation of China
- Beijing Municipal Natural Science Foundation
- Beijing Nova Program
- National Key Research and Development Program of China