LATS2 and FAT4 as key candidate genes of hippo pathway associated with the risk and progression of breast cancer: an in-silico approach
LATS2 and FAT4 genes of the hippo pathway have shown an interesting association with overall survival, hypermethylation, genetic alterations, and decreased expression levels in the breast cancer cohort. Our findings suggest that both of these genes are associated with breast cancer progression and diagnosis and can be utilized as predictive biomarkers by oncologists for personalized therapy in patients.
Authors
- Sadaf Anwar (ORCID: https://orcid.org/0000-0001-8153-2321)
- Mubashir Zafar (ORCID: https://orcid.org/0000-0002-7440-0635)
- Tulika Bhardwaj (ORCID: https://orcid.org/0000-0001-6382-2413)
- Abrar Ali (ORCID: https://orcid.org/0000-0002-0563-3742)
- Sheersh Massey
- Abdulaziz A. Aloliqi (ORCID: https://orcid.org/0000-0002-7108-0541)
- Kapil Dev (ORCID: https://orcid.org/0000-0002-3995-2370)
- Malik Asif Hussain
- Sadaf Sadaf
Institutions
- Qassim University (SA)
- University of Calgary (CA)
- Department of Biotechnology (IN)
- University of Ha'il (SA)
- Jamia Millia Islamia (IN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1038/s41598-024-79688-2
- Citations
- 2
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.65