PEG-BCT-100 and Canavanine Synergistically Induce Apoptosis in Arginine Biosynthetic Enzyme-Deficient Pancreatic Cancer
This study investigates the synergistic antitumor effect of PEG-BCT-100, an arginase, in clinical trials, with canavanine in pancreatic cancer, in vitro and in vivo. The treatment induces cancer cell apoptosis while sparing normal fibroblasts. Our findings suggest heightened susceptibility of pancreatic tumors deficient in arginine biosynthesis enzymes ASS1 and OTC.
Authors
- Tsz Tung Kwong (ORCID: https://orcid.org/0000-0002-1870-1046)
- Landon L. Chan (ORCID: https://orcid.org/0000-0002-1306-5896)
- Stephen L. Chan (ORCID: https://orcid.org/0000-0001-8998-5480)
- Ksh Chok (ORCID: https://orcid.org/0000-0001-7921-3807)
- Chi Hang Wong (ORCID: https://orcid.org/0000-0003-4157-6287)
- Paul N. Cheng
- Anthony W.H. Chan (ORCID: https://orcid.org/0000-0002-1771-163X)
- Hao Hao Deng
Institutions
- Chinese University of Hong Kong (HK)
- NanoBioImaging (China) (CN)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0425
- Citations
- 3
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16