Olorofim demonstrates <i>in vitro</i> activity against <i>Coccidioides</i> species, including isolates against which fluconazole has reduced activity
We evaluated the <i>in vitro</i> activity of olorofim against <i>Coccidioides</i> species. Olorofim demonstrated potent <i>in vitro</i> activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008-0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008-0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).
Authors
- Hoja Patterson
- Víctor García (ORCID: https://orcid.org/0000-0001-6667-7098)
- Thomas F. Patterson (ORCID: https://orcid.org/0000-0002-9513-7127)
- Nathan P. Wiederhold (ORCID: https://orcid.org/0000-0002-2225-5122)
- George R. Thompson (ORCID: https://orcid.org/0000-0001-7093-5379)
- Dora Ferrer
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- University of California Davis Medical Center (US)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1128/aac.00988-24
- Citations
- 4
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Pfizer
- Gilead Sciences
- Cidara Therapeutics
- Amplyx
- Astellas Pharma