Nucleus accumbens shell electrical lesion attenuates seizures and gliosis in chronic temporal lobe epilepsy rats
In the present study, the NAcSh electrical lesion exhibited a definitive therapeutic effect on the chronic TLE rat model, potentially due to decreased hippocampal TLE-induced activation of glial cells and neuron loss. In conclusion, our results indicated that the NAcSh is a promising therapeutic target for TLE and possesses high potential for clinical application.
Authors
- Zibin Song
- Yonghua Cai (ORCID: https://orcid.org/0000-0001-8216-9843)
- Kewan Wang
- Xingqin Wang (ORCID: https://orcid.org/0000-0002-7215-7926)
- Hao Long
- Shuaishuai Xue (ORCID: https://orcid.org/0000-0002-7467-6703)
- Yangqi Mao
- Ye Song (ORCID: https://orcid.org/0000-0003-3101-1143)
- Peiyao Yi (ORCID: https://orcid.org/0000-0001-8016-853X)
- Zhengming Zhan
- Kaijun Yang (ORCID: https://orcid.org/0000-0003-0085-9395)
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Epileptic Disorders
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1002/epd2.20316
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province