Longitudinal decline in DAT binding in Parkinson’s disease: connections with sleep disturbances
Our findings support the role of striatal DA dysfunction in sleep disturbances in early PD patients. Furthermore, we demonstrated that genetic variations in causative genes of PD contribute to the development of sleep disturbances. Striatal DAT imaging may be a useful risk indicator for sleep disturbances, providing early intervention strategies.
Authors
- Junli Ren
- Zihan Jiang (ORCID: https://orcid.org/0000-0003-0632-7402)
- Zijia Liu (ORCID: https://orcid.org/0009-0004-2501-8570)
- Xiaotong Fu
- Dehao Yang (ORCID: https://orcid.org/0000-0002-4129-9761)
- Tingxuan Zhang
- Yusheng Zhu
- Haobo Xie
- Yiyun Weng (ORCID: https://orcid.org/0000-0002-1407-4276)
- Shishu Zhang (ORCID: https://orcid.org/0009-0005-4154-4586)
- Yaoying Ge
- Guangyong Chen (ORCID: https://orcid.org/0000-0003-1818-6280)
- Jinxiu Zhang (ORCID: https://orcid.org/0000-0003-1422-6126)
- Junchao Wang (ORCID: https://orcid.org/0000-0002-2127-097X)
- Ruotong Yao
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Ruian People's Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1186/s12916-024-03766-5
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Celgene
- Neurocrine Biosciences
- Verily Life Sciences
- Voyager Therapeutics
- National Natural Science Foundation of China
- Servier
- H. Lundbeck A/S
- Sun Pharma
- Genentech
- Allergan
- Avid Radiopharmaceuticals
- Fundamental Research Funds for the Central Universities
- Natural Science Foundation of Zhejiang Province