Promoting Antiviral Access and Adherence in the Expansion of Hepatitis B Prevention Programs: Insights From the Democratic Republic of Congo

Hepatitis B virus (HBV) antiviral administration and adherence are essential to reach the World Health Organization's 2030 hepatitis elimination goals. As HBV treatment guidelines are now simplified and expanded, adherence to treatment will be critical, but challenges to adherence are poorly studied. After introducing tenofovir disoproxil fumarate (TDF) monotherapy to expectant mothers with high-risk HBV in Kinshasa, DRC, we conducted semi-structured interviews to understand medication adherence behaviors, to complement pill counts and measurement of TDF metabolite levels. Key facilitators of adherence identified included trust in healthcare workers, a better understanding of HBV, and family support. Identified barriers included fear of stigma and low health literacy. Knowledge about HBV disease remains low, underscoring the importance of ongoing education of clinic staff and patients alike.

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Publication Details

Journal
Journal of the Pediatric Infectious Diseases Society
Published
2024-11-21
DOI
https://doi.org/10.1093/jpids/piae081
Citations
2
Primary Topic
HIV/AIDS Research and Interventions
Type
article
Field-Weighted Citation Impact
0.78
Controls
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article

Promoting Antiviral Access and Adherence in the Expansion of Hepatitis B Prevention Programs: Insights From the Democratic Republic of Congo

Patrick Ngimbi, Kristin Banek, Sarah Ntambua, Sahal Thahir et al.
2 citations
Journal of the Pediatric Infectious Diseases Society
HIV/AIDS Research and Interventions
0.78
article

Promoting Antiviral Access and Adherence in the Expansion of Hepatitis B Prevention Programs: Insights From the Democratic Republic of Congo

Patrick Ngimbi, Kristin Banek, Sarah Ntambua, Sahal Thahir, Camille Morgan, Martine Tabala, Charles Mbendi, Didine Kaba, Peyton Thompson, Jonathan B. Parr, Marcel Yotebieng, Jolie Matondo, Melchior Mwandagalirwa Kashamuka
article en
2 citations

Abstract

Hepatitis B virus (HBV) antiviral administration and adherence are essential to reach the World Health Organization's 2030 hepatitis elimination goals. As HBV treatment guidelines are now simplified and expanded, adherence to treatment will be critical, but challenges to adherence are poorly studied. After introducing tenofovir disoproxil fumarate (TDF) monotherapy to expectant mothers with high-risk HBV in Kinshasa, DRC, we conducted semi-structured interviews to understand medication adherence behaviors, to complement pill counts and measurement of TDF metabolite levels. Key facilitators of adherence identified included trust in healthcare workers, a better understanding of HBV, and family support. Identified barriers included fear of stigma and low health literacy. Knowledge about HBV disease remains low, underscoring the importance of ongoing education of clinic staff and patients alike.

Journal of the Pediatric Infectious Diseases SocietyVol. 13(Supplement_5)
University of North Carolina at Chapel Hill (US), Ministry of Public Health (CD), Albert Einstein College of Medicine (US), University of Kinshasa (CD)
Quality Education
Openalex Percentile: Top 26%
HIV/AIDS Research and Interventions
0.78
DOIOpen Access PDFOpenAlex
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