G-quadruplex-guided bifunctional platinum complexes induce multiple pyroptosis pathways for antitumor therapy
BiPP reduces G4 oncogene mRNA like c-MYC and VEGF, inhibits tumor growth, activates immune pathways, and induces pyroptosis by lowering BIRC7 and increasing cleaved caspase-3 and GSDME-N, forming an highly integrated antitumor immune network.
Authors
- Liu‐Yi Liu (ORCID: https://orcid.org/0000-0001-9467-5014)
- Xushen Xiong (ORCID: https://orcid.org/0000-0001-7090-7503)
- You‐Liang Zeng
- Zong‐Wan Mao (ORCID: https://orcid.org/0000-0001-7131-1154)
- Tianzhu Ma
- Wenting Liu (ORCID: https://orcid.org/0000-0003-1461-3740)
- Ke Ding (ORCID: https://orcid.org/0000-0001-6837-5878)
Institutions
- Sun Yat-sen University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Inorganic Chemistry Frontiers
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1039/d4qi02098g
- Citations
- 2
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.57