Cooperative photoredox and N-heterocyclic carbene-catalyzed formal C–H acylation of cyclopropanes <i>via</i> a deconstruction–reconstruction strategy
Cyclopropanes are ubiquitous and key structural motifs in commercially available drugs and bioactive molecules. Herein, we present regio-selective acylation of aryl cyclopropanes with cooperative photoredox and N-heterocyclic carbene catalysis. This approach involves a deconstruction-reconstruction strategy <i>via</i> γ-chloro-ketones as intermediates and fulfills the formal C(sp<sup>3</sup>)-H functionalization of cyclopropanes.
Authors
- Xiaoyu Yan (ORCID: https://orcid.org/0000-0003-3973-3669)
- Fan Gao (ORCID: https://orcid.org/0009-0006-7518-3835)
- Tian Wang
Institutions
- Renmin University of China (CN)
Publication Details
- Journal
- Chemical Science
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1039/d4sc06355d
- Citations
- 9
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.25
Funders
- National Natural Science Foundation of China
- Renmin University of China
- Fundamental Research Funds for the Central Universities