Neutralizing the IL-7Rα limits injury in experimental ANCA-associated glomerulonephritis
Intrarenal effector memory and exhausted CD4+ and CD8+ T cells are present in experimental anti-MPO glomerulonephritis. Neutralizing effector T cells via the IL-7Rα after the induction of autoimmunity limits intrarenal inflammation and disease. IL-7Rα may be a therapeutic target in ANCA-associated vasculitis.
Authors
- Alana Auden
- Kim M. O’Sullivan (ORCID: https://orcid.org/0000-0002-3098-7948)
- A. Richard Kitching (ORCID: https://orcid.org/0000-0002-2713-2391)
- Limy Wong (ORCID: https://orcid.org/0000-0003-0604-0380)
- Juli Jaw
- Peemapat Prakongtham
- Maliha A. Alikhan (ORCID: https://orcid.org/0000-0002-2578-3457)
- Kazuya Kishimoto
Institutions
- Monash Medical Centre (AU)
- Eastern Health (AU)
- Monash Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1093/ndt/gfae276
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00