Recombinant soluble type I interferon receptor exerts antiviral activity by inducing proteins related to autophagy
r-sIFNAR2 exhibits significant antiviral activity regardless of the expression system used for its production and good safety profile, suggesting its use as a potential antiviral drug. Proteins related to autophagy are involved in the protection from the virus. This study highlights the biological relevance of soluble cytokine receptors as effectors so far overlooked.
Authors
- Yolanda López-Moreno (ORCID: https://orcid.org/0000-0003-2861-5915)
- Pedro Jesús Serrano-Castro (ORCID: https://orcid.org/0000-0002-3414-2707)
- Isabel Brichette-Mieg (ORCID: https://orcid.org/0000-0002-1269-0729)
- Begoña Oliver‐Martos (ORCID: https://orcid.org/0000-0003-3452-2942)
- Nicolás Lundahl Ciano-Petersen (ORCID: https://orcid.org/0000-0001-9555-4847)
- J.L. Rodriguez-Bada
- Pablo Aliaga-Gaspar
- Óscar Fernández-Fernández
- MdM Fernández-Arjona
Institutions
- Hospital Regional Universitario de Málaga (ES)
- Instituto de Investigación Biomédica de Málaga (ES)
- Universidad de Málaga (ES)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1016/j.biopha.2024.117678
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III