Visible light induced hydroxyfluoroalkylation of quinoxalin-2(1<i>H</i>)-ones with <i>N</i>-trifluoroethoxyphthalimide under catalyst-free conditions
For the first time, we achieved visible light-induced direct C3-hydroxyfluoroalkylation of quinoxalin-2(1<i>H</i>)-ones using <i>N</i>-trifluoroethoxyphthalimide as the trifluoroethanol radical precursor, without the need for a photocatalyst. The metal-free and catalyst-free nature of this method makes it an efficient and environmentally friendly approach for synthesizing C3-hydroxyfluoroalkylated quinoxalin-2(1<i>H</i>)-ones.
Authors
- Kui Lu (ORCID: https://orcid.org/0000-0002-9685-2691)
- Xia Zhao (ORCID: https://orcid.org/0000-0001-9477-5912)
- Siqi Li (ORCID: https://orcid.org/0000-0001-9720-826X)
- Jing Liu (ORCID: https://orcid.org/0000-0003-3049-3566)
- Liting Liu (ORCID: https://orcid.org/0000-0002-6247-9147)
- Mengfei Yang
Institutions
- Tianjin University of Science and Technology (CN)
- Tianjin Normal University (CN)
- China International Science and Technology Cooperation (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1039/d4ob01616e
- Citations
- 3
- Primary Topic
- Synthesis and Biological Evaluation
- Type
- article
- Field-Weighted Citation Impact
- 0.75