EZH2 promotes B-cell autoimmunity in primary Sjogren's syndrome via METTL3-mediated m6A modification
The upregulation of EZH2 mediated by METTL3 is implicated in the B-cell autoimmune response in pSS. Inhibition of EZH2 presents a promising therapeutic strategy for pSS treatment.
Authors
- Hui Luo (ORCID: https://orcid.org/0000-0001-5593-8563)
- Liqing Ding (ORCID: https://orcid.org/0009-0006-6990-7737)
- Meidong Liu
- Yisha Li (ORCID: https://orcid.org/0000-0001-5604-0755)
- Huali Zhang (ORCID: https://orcid.org/0000-0002-0788-7092)
- Muyao Guo (ORCID: https://orcid.org/0000-0003-1347-0848)
- Ke Liu (ORCID: https://orcid.org/0000-0003-0617-5613)
- Ying Zhang (ORCID: https://orcid.org/0009-0002-9613-8903)
- Muyuan Li (ORCID: https://orcid.org/0009-0005-3231-8341)
- Xiaoxia Zuo
- Yiying Yang (ORCID: https://orcid.org/0000-0001-7755-7956)
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal of Autoimmunity
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1016/j.jaut.2024.103341
- Citations
- 8
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hunan Province
- Postdoctoral Research Foundation of China