Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains <i>in vitro</i> due to zinc(II) complexation
This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral low-molecular agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used in the form of zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of an influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.
Authors
- Т. В. Гребенникова (ORCID: https://orcid.org/0000-0002-6141-9361)
- Varvara Vladimirovna Avdeeva (ORCID: https://orcid.org/0000-0002-0655-1052)
- Svetlana E. Nikiforova (ORCID: https://orcid.org/0000-0003-1844-266X)
- N. V. Breslav (ORCID: https://orcid.org/0000-0002-6946-5119)
- Ivan I. Myshletsov
- Tatyana E. Savochkina (ORCID: https://orcid.org/0000-0003-4366-8476)
- Т. М. Garaev (ORCID: https://orcid.org/0000-0002-3651-5730)
- Еlena А. Malinina (ORCID: https://orcid.org/0000-0001-9689-2039)
- I. I. Yudin
- А. S. Krepkaya
Institutions
- Russian Academy of Sciences (RU)
- Institute of General and Inorganic Chemistry (BG)
- Ministry of Health of the Russian Federation (RU)
Publication Details
- Journal
- Журнал неорганической химии
- Published
- 2024-11-21
- DOI
- https://doi.org/10.31857/s0044457x24050113
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00