Use of a Hyperoxic Heated Helium-Oxygen Mixture in an Experimental Model of Cerebral Arterial Air Embolism

Arterial gas embolism can result from complications related to medical and surgical procedures, as well as a direct entry of air into the systemic circulation due to the disruption of the alveolar-capillary barrier. Since air in the arterial circulation can lead to organ ischemia, this life-threatening pathology requires prompt intervention. In this study, we demonstrated the effectiveness of using a hyperoxic heated helium-oxygen mixture in cerebral arterial air embolism. Oxygen therapy under normobaric conditions did not affect the outcome of arterial air embolism. A continuous inhalation session for 30 min, or intermittent inhalation sessions 3 times for 5 min each, eliminated foci of ischemic stroke in rats.