Pharmacological Correction of Physical Performance in Male Rats with Peptide Preparations when Changing the Lighting Regime

This study examined the effect of peptide extracts from the epiphysis-pituitary gland of reindeer ( Rangifer tarandus ) and delta-sleep-inducing peptide, simulating modified release, on the physical performance of male rats under conditions of light desynchronosis. All tested agents had a positive effect on the physical performance of male rats, increasing the duration of the first and second swim, depending on the lighting regime and the degree of desynchronization. In addition, the effectiveness of the tested agents was also noted after a course of intranasal administration (formed light desynchronosis), which indicates their prolonged action. This method of pharmacological tuning of the body’s circadian oscillators by agents of a peptide nature with a modified release can be used to develop a scheme for correcting light desynchronosis.