Modeling of Hypobaric and Hemic Hypoxia

The mechanisms of hypoxia development at various levels – from molecular and cellular to organ and systemic – continue to attract research attention. At present, the pathogenetic demonstration of a new principle of pharmacological correction of metabolism and dysfunction in hypoxia seems relevant. In this work, hypobaric and hemic hypoxia is modeled, and the main markers for assessing the condition of animals are identified. Animals from the model group showed statistically significantly lower results in behavioral tests, which confirmed the success of modeling. The tested model and the markers for assessing the condition can be used to determine the antihypoxic effect of active medicinal substances.