Anxiolytic Properties of the TRPV1 Receptor Antagonist in a Dark/Light Chamber Test on ICR Mice

TRPV1, a key mediator of nociceptive signaling, is widely distributed in various tissues and cells, including the central nervous system. The regulatory activity of TRPV1 affects neural desensitization, pain transmission, and neurotransmitter systems. The use of the beneficial peptide APHC3 as a selective antagonist of TRPV1 is a method for studying the blocking of this channel at the level of anxiety and is a response to stress in mice. The findings improve our understanding of the influence of TRPV1 on the moderation of emotional states. This study has important implications for understanding the effects of TRPV1 on stress states in ICR mice and may also contribute to medical and biomedical research.