Stress-Protective Properties of the APHC3 Peptide in an Elevated Cross-Shaped Maze Test in ICR Mice

TRPV1, which plays a key role in transmitting pain signals, is widely distributed in various tissues and cells, including the central nervous system. Activation or suppression of TRPV1 influences neuronal desensitization, pain signal transmission, and regulation of neurotransmitter systems. The APHC3 peptide, as a selective antagonist of TRPV1, is used to investigate the effects of blocking this channel in terms of anxiety and stress response in mice. The results of studies can indicate the influence of TRPV1 on the formation of emotional states. This study is important for understanding the impact of TRPV1 channels on stress in ICR mice, being promising for further research in the field of biomedicine and biomodeling.