Reproductive Disorders in Mothers and Offspring of Rats in Gestational Diabetes Modelled with a High-Calorie Diet in Combination with Tyloxapol

The absence of a generally accepted model of gestational diabetes makes the task of its search and development highly relevant. The conducted experiments found that a high-calorie diet in combination with tyloxapol administration in various modes in the second half of pregnancy of Wistar rats leads to impaired glucose tolerance, an increase in the level of DNA damage in the organs of offspring, and deviations in the postnatal period of development. The proposed model can be used to search for pharmacological correction of reproductive disorders in gestational diabetes.