Taxifolin Antihypertensive Effect in an Age-Related Hypertension Model

This work shows that age-related arterial hypertension in Wistar rats develops with age, in 52% of 18-monthold animals versus 33% of 3-month-old animals. Effects of Taxifolin at a dose of 100 mg/kg, administered intraperitoneally for a week, on blood pressure (BP) and biochemical parameters in 18-month-old and 3-month-old animals were studied. The experimental animals were divided into two groups, those normotensive (BP<115 mmHg) and hypertensive (BP>115 mmHg). It was shown that a weekly course of Taxifolin leads to a significant decrease in blood pressure in hypertensive 18-month-old animals with no effect on blood pressure in normotensive animals. In addition, some age-related changes in the biochemical parameters of blood under the influence of Taxifolin were revealed.