Effect of Xylazine/Zoletil Anesthesia on the Survival of Mice after Exposure to Radiations with Different Values of Linear Energy Transfer

The survival of mice was determined 30 days after exposure to protons, carbon ions, or X-rays in the presence and absence of xylazine-zoletil anesthesia. The anesthesia used was shown to increase the lifespan of mice during the specified period for photons and most applied doses of protons and carbon. The maximum effect of anesthesia was observed when irradiated with carbon ions (by 3.3 times), with protons (by 1.7 times), and with X-ray radiation (by 1.7–2 times), which should be taken into account when selecting doses. This indicates the specificity of the combined effect of anesthesia and the physical characteristics of radiation.