Cover Feature: SuFEx‐Functionalized Quinones via Ruthenium‐Catalyzed C−H Alkenylation: A Potential Building Block for Bioactivity Valorization (Chem. Asian J. 22/2024)
A direct and modular C-H activation protocol has been employed to develop a novel route for the direct access to ethenesulfonyl-fluorinated 1,4-naphthoquinoidal structures. This culminated in the development of quinone/SuFEx scaffolds with moderate to good yields, utilizing the power of ruthenium catalysis. The identification of prospective trypanocidal prototypes was the result of the evaluation of these new quinoidal/SuFEx hybrids against the trypomastigote forms of Trypanosoma cruzi, the causative agent of Chagas disease. More details can be found in article number e202400757 by Guilherme A. M. Jardim, Eufrânio N. da Silva Júnior, and co-workers.
Authors
- Rubem F. S. Menna‐Barreto (ORCID: https://orcid.org/0000-0002-1352-0641)
- Joyce C. Oliveira
- Maria H. Araújo (ORCID: https://orcid.org/0000-0002-2609-0281)
- Renata G. Almeida (ORCID: https://orcid.org/0000-0003-2896-0487)
- Guilherme A. M. Jardim (ORCID: https://orcid.org/0000-0002-9882-3085)
- Eufrânio N. da Silva Júnior (ORCID: https://orcid.org/0000-0003-1281-5453)
- Felipe Fantuzzi (ORCID: https://orcid.org/0000-0002-8200-8262)
- João Honorato (ORCID: https://orcid.org/0000-0002-1127-6083)
- Esther R. S. Paz (ORCID: https://orcid.org/0000-0001-5489-5100)
- Cauê P. Souza (ORCID: https://orcid.org/0000-0001-5545-004X)
- Victor F. S. Ramos
- Breno U. Abreu
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade Federal de São Carlos (BR)
- Universidade de São Paulo (BR)
- University of Kent (GB)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1002/asia.202482202
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00