Factors associated with low health-related quality of life in persons with multiple sclerosis: A quantile-based segmentation approach
Our segmentation method identified symptom burden and MS severity as factors associated with low HRQoL. Pharmacological and non-pharmacological MS symptom management, especially for depression, fatigue, pain, and muscle weakness, may warrant increased attention to preserve or improve HRQoL.
Authors
- Benjamin Victor Ineichen (ORCID: https://orcid.org/0000-0003-1362-4819)
- Anke Salmen (ORCID: https://orcid.org/0000-0002-4751-299X)
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Viktor von Wyl (ORCID: https://orcid.org/0000-0002-8754-9797)
- Christian P. Kamm (ORCID: https://orcid.org/0000-0002-3906-0161)
- Stefania Iaquinto (ORCID: https://orcid.org/0000-0001-5808-9026)
- Chiara Zecca (ORCID: https://orcid.org/0000-0002-9990-3431)
- Pascal Benkert (ORCID: https://orcid.org/0000-0001-6525-8174)
- Caroline Pot (ORCID: https://orcid.org/0000-0002-1146-3129)
- Sabin Ammann (ORCID: https://orcid.org/0000-0003-0060-1925)
- Patrick Roth
- Pasquale Calabrese
- Luisa Hofer
Institutions
- University of Bern (CH)
- University of Lucerne (CH)
- University of Basel (CH)
- University of Zurich (CH)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- Ospedale regionale di Lugano (CH)
- University Hospital of Zurich (CH)
- St. Josef-Hospital (DE)
- Università della Svizzera italiana (CH)
- Ruhr University Bochum (DE)
- University of Lausanne (CH)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1371/journal.pone.0312486
- Citations
- 3
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- Bristol-Myers Squibb
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Celgene
- CSL Behring
- Universität Basel
- Novocure
- International Progressive MS Alliance
- Multiple Sclerosis Society
- National Research Foundation
- Centre Hospitalier Universitaire Vaudois
- Schweizerische Multiple Sklerose Gesellschaft
- H. Lundbeck A/S