Intestinal Drug Absorption After Subarachnoid Hemorrhage and Elective Neurosurgery: Insights From Esomeprazole Pharmacokinetics
Following SAH, significantly reduced drug absorption may be attributed to decreased intestinal motility and compromised intestinal mucosal function. Clinicians should anticipate the reduced effectiveness of enterally administered medications for at least seven days after high-grade SAH.
Authors
- Justus Stenzig
- Tammam Abboud (ORCID: https://orcid.org/0000-0003-4379-6961)
- J Sindern
- Jürgen Brockmöller (ORCID: https://orcid.org/0000-0002-8854-1340)
- Dorothée Mielke (ORCID: https://orcid.org/0000-0002-1462-4864)
- Onnen Moerer (ORCID: https://orcid.org/0000-0002-4210-388X)
- Beate Kranawetter (ORCID: https://orcid.org/0009-0004-5557-6098)
- Lars-Olav Harnisch (ORCID: https://orcid.org/0000-0002-4935-3240)
- Anne Hapke
- Ellen Bruns
- Veit Rohde
Institutions
- Universität Hamburg (DE)
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Universitätsmedizin Göttingen (DE)
- Universitätsklinikum Aachen (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1097/ccm.0000000000006512
- Citations
- 3
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- CSL Behring
- Bundesministerium für Bildung und Forschung