Candidate serum protein biomarkers for active pulmonary tuberculosis diagnosis in tuberculosis endemic settings
We have identified eight protein markers that reliably differentiate active PTB from ORD irrespective of LTBI presence. Further large-scale validation and translation of these protein markers into a user-friendly and affordable point-of-care test hold the potential to significantly enhance TB control in high-burden regions.
Authors
- Anne L Piantadosi (ORCID: https://orcid.org/0000-0002-5942-1534)
- Azeb Tarekegn
- Biniam Wondale
- Claudia Fredolini (ORCID: https://orcid.org/0000-0002-7674-2014)
- Adane Mihret (ORCID: https://orcid.org/0000-0003-3183-4772)
- Tewodros Tariku Gebresilase (ORCID: https://orcid.org/0000-0003-2608-2465)
- Teklu Wegayehu (ORCID: https://orcid.org/0000-0003-1719-6321)
- Sosina Ayalew
- Bamlak Tessema
- Maryam Sahi (ORCID: https://orcid.org/0000-0002-0147-2937)
- Filippos Admasu
Institutions
- Emory University (US)
- Science for Life Laboratory (SE)
- Armauer Hansen Research Institute (ET)
- Arba Minch University (ET)
- Addis Ababa University (ET)
- East China Normal University (CN)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1186/s12879-024-10224-3
- Citations
- 8
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- International Society for Infectious Diseases
- Armauer Hansen Research Institute
- Science for Life Laboratory