Primary Progressive Aphasia in Italian and English
Language-specific characteristics influenced PPA phenotypes, with more frequent expressive agrammatism in Italian (reflecting its morphologic complexity), more frequently impaired word processing in English (reflecting its articulatory, acoustic, and orthographic complexity), and increased prevalence of mPPA in Italian. These findings have implications for PPA diagnosis and management. Limitations of test heterogeneity and cohort size should be addressed in future, prospective, multicenter initiatives using cross-linguistic tools.
Authors
- Jessica Jiang (ORCID: https://orcid.org/0000-0002-7074-3032)
- Sandro Sorbi (ORCID: https://orcid.org/0000-0002-0380-6670)
- Valentina Bessi (ORCID: https://orcid.org/0000-0002-6176-3584)
- Anthipa Chokesuwattanaskul (ORCID: https://orcid.org/0000-0001-7973-8267)
- Sonia Padiglioni
- Giulia Giacomucci (ORCID: https://orcid.org/0000-0002-8711-331X)
- Carmen Morinelli
- Salvatore Mazzeo (ORCID: https://orcid.org/0000-0001-5985-5060)
- Benedetta Nacmias (ORCID: https://orcid.org/0000-0001-9338-9040)
- Valentina Moschini
- Jason D. Warren (ORCID: https://orcid.org/0000-0002-5405-0826)
- Chris JD Hardy (ORCID: https://orcid.org/0000-0002-4900-6492)
- Jeremy C. S. Johnson (ORCID: https://orcid.org/0000-0002-4265-7997)
- Jonathan D. Rohrer (ORCID: https://orcid.org/0000-0002-6155-8417)
- Silvia Bagnoli (ORCID: https://orcid.org/0000-0002-4373-6611)
- Assunta Ingannato (ORCID: https://orcid.org/0000-0003-4955-0321)
- Anna Volkmer (ORCID: https://orcid.org/0000-0002-4149-409X)
- Ella Brooks
Institutions
- UK Dementia Research Institute (GB)
- University College London (GB)
Publication Details
- Journal
- Neurology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1212/wnl.0000000000210058
- Citations
- 10
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 3.43
Funders
- Wellcome Trust
- Brain Research UK
- UK Research and Innovation
- Alzheimer's Society
- National Institute for Health and Care Research
- Department of Health and Social Care
- University College London
- Regione Toscana
- UK Dementia Research Institute
- Medical Research Council
- Invention for Innovation