The Role of Complement Activation in IgM M-Protein–Associated Neuropathies
Anti-MAG antibody titers correlate with the level of complement activation in both ELISA and cell-based systems. However, clinical characteristics of IgM-associated polyneuropathy do not or only weakly correlate with titers or the level of complement deposition. The lack of clear correlations between complement activation and clinical characteristics does, at this stage, not support the use of complement inhibitors in the treatment of IgM-associated polyneuropathy.
Authors
- W. Ludo van der Pol (ORCID: https://orcid.org/0000-0002-8970-2740)
- Alexander F. J. E. Vrancken (ORCID: https://orcid.org/0000-0003-4649-6534)
- Kevin Budding (ORCID: https://orcid.org/0000-0002-3827-7131)
- Monique C. Minnema (ORCID: https://orcid.org/0000-0002-3139-8379)
- Kim Dijkxhoorn (ORCID: https://orcid.org/0009-0005-9692-9360)
- Johannes P. M. van de Mortel (ORCID: https://orcid.org/0000-0002-9956-744X)
- Nicolette C. Notermans (ORCID: https://orcid.org/0000-0002-9363-4103)
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1212/nxi.0000000000200339
- Citations
- 9
- Primary Topic
- Peripheral Neuropathies and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.32
Funders
- Prinses Beatrix Spierfonds
- Stichting Spieren voor Spieren