Outcome and management of patients with hepatocellular carcinoma who achieved a complete response to immunotherapy-based systemic therapy
Overall survival and recurrence-free survival of patients with CR-mRECIST-only and CR-RECISTv1.1 were excellent, and 6 of 7 patients with CR-mRECIST-only who underwent surgical conversion therapy had pathological CR. Despite potential limitations, these findings support the use of mRECIST in the context of immunotherapy for clinical decision-making. When considering ICI discontinuation, treatment for at least 6 months beyond CR seems advisable.
Authors
- David James Pinato (ORCID: https://orcid.org/0000-0002-3529-0103)
- Michael Schultheiß (ORCID: https://orcid.org/0000-0001-8000-1721)
- Arndt Weinmann (ORCID: https://orcid.org/0000-0003-1198-1716)
- Ignazio Piseddu (ORCID: https://orcid.org/0000-0001-8331-9778)
- Florian Paul Reiter (ORCID: https://orcid.org/0000-0003-3807-1456)
- Alexander B. Philipp (ORCID: https://orcid.org/0000-0002-0215-9977)
- Najib Ben Khaled (ORCID: https://orcid.org/0000-0002-9681-2542)
- Pei‐Chang Lee (ORCID: https://orcid.org/0000-0002-7492-2484)
- Katharina Lampichler (ORCID: https://orcid.org/0000-0002-9719-4694)
- Anna Lena Saborowski (ORCID: https://orcid.org/0000-0003-4857-4276)
- Antonio D’Alessio (ORCID: https://orcid.org/0000-0002-9164-3671)
- Fabian Finkelmeier (ORCID: https://orcid.org/0000-0001-8559-9910)
- Katharina Pomej (ORCID: https://orcid.org/0000-0002-2807-3565)
- Xiao Yuan
- Florian Hucke (ORCID: https://orcid.org/0000-0001-7887-3440)
- Rudolf E Stauber (ORCID: https://orcid.org/0000-0002-3687-9331)
- Masatoshi Kudo (ORCID: https://orcid.org/0000-0002-4102-3474)
- Jiang Guo (ORCID: https://orcid.org/0000-0001-8297-5458)
- Bertram Bengsch (ORCID: https://orcid.org/0000-0003-2552-740X)
- Long Cheng (ORCID: https://orcid.org/0000-0002-8483-0495)
- Caterina Vivaldi (ORCID: https://orcid.org/0000-0001-9307-2326)
- Neehar D. Parikh (ORCID: https://orcid.org/0000-0002-5874-9933)
- Bernhard Scheiner (ORCID: https://orcid.org/0000-0002-4904-5133)
- Anwaar Saeed (ORCID: https://orcid.org/0000-0001-8024-9401)
- Andreas Geier (ORCID: https://orcid.org/0000-0002-9626-5083)
- Joao Gorgulho (ORCID: https://orcid.org/0000-0003-1986-8208)
- Fanpu Ji (ORCID: https://orcid.org/0000-0002-1463-8035)
- Melanie Bathon
- Vera Himmelsbach
- Hung‐Wei Wang (ORCID: https://orcid.org/0000-0001-6574-1561)
- Matthias Pinter (ORCID: https://orcid.org/0000-0002-7260-532X)
- Gianluca Masi (ORCID: https://orcid.org/0000-0001-8329-8989)
- Birgit Schwacha-Eipper
- Marino Venerito (ORCID: https://orcid.org/0000-0001-8581-0974)
- Lorenza Rimassa (ORCID: https://orcid.org/0000-0001-9957-3615)
- Hong Jae Chon (ORCID: https://orcid.org/0000-0002-6979-5812)
- Friedrich Sinner (ORCID: https://orcid.org/0000-0003-0524-8833)
- Yi‐Hsiang Huang (ORCID: https://orcid.org/0000-0001-5241-5425)
- Jeroen Dekervel (ORCID: https://orcid.org/0000-0001-7208-3480)
- Beodeul KANG (ORCID: https://orcid.org/0000-0002-4830-3559)
- Arndt Vogel (ORCID: https://orcid.org/0000-0003-0560-5538)
- Mohamed Bouattour (ORCID: https://orcid.org/0000-0002-3919-4135)
- Michael A Trauner (ORCID: https://orcid.org/0000-0002-1275-6425)
- Frederik Peeters (ORCID: https://orcid.org/0000-0002-0081-4800)
- Angela Djanani (ORCID: https://orcid.org/0000-0002-2997-5157)
- Giulia Tesini (ORCID: https://orcid.org/0000-0001-8104-6585)
- Juraj Prejac (ORCID: https://orcid.org/0000-0003-1981-9369)
- Anja Krall
- Lorenz Balcar (ORCID: https://orcid.org/0000-0002-6708-3061)
- Valentina Zarka
- Naoshi Nishida (ORCID: https://orcid.org/0000-0001-6581-7896)
- Jean‐François Dufour (ORCID: https://orcid.org/0000-0002-8062-1346)
- Xu Gao (ORCID: https://orcid.org/0000-0003-2014-5875)
- Kornelius Schulze
- Johann von Felden
- Iuliana‐Pompilia Radu
- Markus Peck-Radosavljevic
- Gordan Adžić
Institutions
- University of Pisa (IT)
- Goethe University Frankfurt (DE)
- University of Bern (CH)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Humanitas University (IT)
- University Hospital Centre Zagreb (HR)
- Innsbruck Medical University (AT)
- National Yang Ming Chiao Tung University (TW)
- Universität Hamburg (DE)
- University of Freiburg (DE)
- University of Pittsburgh (US)
- University of Zagreb (HR)
- Capital Medical University (CN)
- China Medical University (TW)
- Universität Innsbruck (AT)
- Johannes Gutenberg University Mainz (DE)
- Medical University of Graz (AT)
- University of Michigan (US)
- Hôpital Beaujon (FR)
- University Hospital of Bern (CH)
- Toronto General Hospital (CA)
- Princess Margaret Cancer Centre (CA)
- Taipei Veterans General Hospital (TW)
- LMU Klinikum (DE)
- Medizinische Hochschule Hannover (DE)
- Klinikum Klagenfurt (AT)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- University Medical Center Hamburg-Eppendorf (DE)
- Universitätsklinikum Würzburg (DE)
- China Medical University Hospital (TW)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- University Hospital Frankfurt (DE)
- CHA University Bundang Medical Center (KR)
- University Hospital Magdeburg (DE)
- CHA University (KR)
- Beijing Ditan Hospital (CN)
- IRCCS Humanitas Research Hospital (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- Imperial College London (GB)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
- Xi'an Jiaotong University (CN)
- Kindai University (JP)
- Otto-von-Guericke-Universität Magdeburg (DE)
- KU Leuven (BE)
Publication Details
- Journal
- Hepatology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1097/hep.0000000000001163
- Citations
- 27
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.98