Inflammatory Waldenström macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort
Inflammatory form of Waldenström macroglobulinemia (iWM) predicts outcomes after immuno-chemotherapy and Bruton tyrosine kinase inhibitors, but its origin is unknown. Here, we unravel increased clonal hematopoiesis in patients with iWM (61% vs 23% in noninflammatory WM), suggesting a contribution of environmental cells to iWM.
Authors
- Marie Templé (ORCID: https://orcid.org/0000-0002-5247-8976)
- Grégory Lazarian (ORCID: https://orcid.org/0000-0002-4315-3440)
- Jehan Dupuis
- Lise Willems (ORCID: https://orcid.org/0000-0001-7866-2571)
- Stéphanie Harel (ORCID: https://orcid.org/0000-0002-9469-8336)
- Frédéric Davi (ORCID: https://orcid.org/0000-0002-3764-063X)
- Stéphanie Poulain (ORCID: https://orcid.org/0000-0002-1792-7270)
- Laureen Chat (ORCID: https://orcid.org/0000-0001-6871-4905)
- Florence Nguyen‐Khac (ORCID: https://orcid.org/0000-0003-3107-6668)
- Bertrand Arnulf (ORCID: https://orcid.org/0000-0001-7719-3611)
- Nathalie Forgeard (ORCID: https://orcid.org/0000-0001-8381-2773)
- Olivier Kosmider (ORCID: https://orcid.org/0000-0002-6021-4057)
- Floriane Theves (ORCID: https://orcid.org/0000-0002-3816-1825)
- Emmanuelle Clappier (ORCID: https://orcid.org/0000-0001-7098-092X)
- Chloé Friedrich (ORCID: https://orcid.org/0000-0002-8640-9776)
- Wendy Cuccuini (ORCID: https://orcid.org/0000-0003-2813-5372)
- Clotilde Bravetti (ORCID: https://orcid.org/0000-0003-1442-8748)
- Karl Balabanian (ORCID: https://orcid.org/0000-0002-0534-3198)
- Dikélélé Elessa (ORCID: https://orcid.org/0000-0003-0926-4611)
- Anne Brignier
- Daphné Krzisch (ORCID: https://orcid.org/0000-0001-7059-5917)
- Alexis Talbot (ORCID: https://orcid.org/0000-0001-6734-413X)
- Olivier Hermine (ORCID: https://orcid.org/0000-0003-2574-3874)
- Marie Passet (ORCID: https://orcid.org/0000-0003-4620-8782)
- Alexandre Terré (ORCID: https://orcid.org/0000-0002-8295-9068)
- Bruno Royer (ORCID: https://orcid.org/0000-0002-8649-7008)
- Pierre-Édouard Debureaux (ORCID: https://orcid.org/0000-0002-2358-4278)
- Damien Roos‐Weil (ORCID: https://orcid.org/0000-0002-7767-755X)
- Marion Espéli (ORCID: https://orcid.org/0000-0001-5005-1664)
- Laurent Frenzel (ORCID: https://orcid.org/0000-0002-6085-2163)
- Didier Bouscary (ORCID: https://orcid.org/0000-0002-5611-7238)
- Marion Malphettes
- Tristan Vaugeois
- William Plas
Institutions
- Délégation Paris 5 (FR)
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Sorbonne Nouvelle (FR)
- Université Paris Cité (FR)
- Saint Louis University Hospital (US)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Lille’s Cardiology Hospital (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Centre de Recherche des Cordeliers (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
- Hôpital Avicenne (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Institut Cochin (FR)
- Hôpital Saint-Louis (FR)
- Institut des Hautes Études du Ministère de l'Intérieur (FR)
- Lymphoma Study Association (FR)
- Hôpital Tenon (FR)
- Institut de recherche Saint-Louis (FR)
Publication Details
- Journal
- Blood
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1182/blood.2024025738
- Citations
- 4
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.75