Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study
In these KEEPS Continuation analyses, there were no long-term cognitive effects of short-term exposure to mHT started in early menopause versus placebo. These data provide reassurance about the long-term neurocognitive safety of mHT for symptom management in healthy, recently postmenopausal women, while also suggesting that mHT does not improve or preserve cognitive function in this population.
Authors
- Rogerio A. Løbo (ORCID: https://orcid.org/0000-0002-1472-8313)
- Carola A. Ferrer Simó
- Hector Salazar (ORCID: https://orcid.org/0009-0007-5184-6996)
- Carey Elizabeth Gleason (ORCID: https://orcid.org/0000-0001-6210-4671)
- Taryn T. James (ORCID: https://orcid.org/0000-0002-6843-8653)
- Frederick Naftolin (ORCID: https://orcid.org/0000-0002-9447-6266)
- Michael Malek‐Ahmadi (ORCID: https://orcid.org/0000-0001-9901-3650)
- Virginia M. Miller (ORCID: https://orcid.org/0000-0003-1251-1388)
- Firat Kara
- JoAnn E. Manson (ORCID: https://orcid.org/0000-0002-9426-7595)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Lubna Pal (ORCID: https://orcid.org/0000-0002-9900-9392)
- Marcelle Ivonne Cedars (ORCID: https://orcid.org/0000-0003-3682-6907)
- Kejal Kantarci (ORCID: https://orcid.org/0000-0002-8001-2081)
- S. Mitchell Harman (ORCID: https://orcid.org/0000-0002-8806-8178)
- N. Maritza Dowling (ORCID: https://orcid.org/0000-0001-8642-7299)
Institutions
- Brigham and Women's Hospital (US)
- Mayo Clinic (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- George Washington University (US)
- WinnMed (US)
- Yale University (US)
- Geriatric Research Education and Clinical Center (US)
- Phoenix VA Health Care System (US)
- William S. Middleton Memorial Veterans Hospital (US)
- Banner Alzheimer’s Institute
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Columbia University (US)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1371/journal.pmed.1004435
- Citations
- 19
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.80
Funders
- Eli Lilly and Company
- Pfizer
- Brigham and Women's Hospital
- Yale University
- Biogen
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- Brigham Research Institute
- National Institute on Aging
- National Center for Advancing Translational Sciences
- Yale Center for Clinical Investigation, Yale School of Medicine