Renal and Vascular Functional Decline in Aged Low Birth Weight Murine Adults
MUN-induced LBW mice experience increased Ang II sensitivity and oxidative stress. The increased Ang II sensitivity and ROS generation influences vascular density and reactivity, which drive an increase in MABP, and a concomitantly decrease in RBF and glomerular filtration. Pharmacological intervention that inhibits AT1R, enhances levels of sGC, reduces ROS, or inhibits toll-like receptor 4 improves vascular and renal function in the LBW adult.
Authors
- Sharath Kandhi (ORCID: https://orcid.org/0000-0002-4674-0325)
- Miroslav Sekulic (ORCID: https://orcid.org/0000-0002-7938-1816)
- Nicolás Vecchio (ORCID: https://orcid.org/0000-0002-1155-9200)
- Michael S. Wolin (ORCID: https://orcid.org/0000-0002-3329-969X)
- May M. Rabadi
- Mia Camilliere
- Monica Verde
- Brian B. Ratliff
Institutions
- New York Medical College (US)
- Columbia University (US)
Publication Details
- Journal
- Kidney & Blood Pressure Research
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1159/000542141
- Citations
- 3
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- New York Medical College
- National Institutes of Health