Intensified Total Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer: Long-term Results of a Prospective Phase II Study
The addition of a targeted agent to induction FOLFOXIRI and oxaliplatin to 5-fluorouracil-based CRT, with the doses and intensities used in this study, resulted in high CR rates. Patients who achieve a CR demonstrate superior DFS compared to patients without CR. Intensified TNT may have the potential to increase survival outcomes. Further research on TNT strategies in LARC is encouraged.
Authors
- Vincenzo Picone (ORCID: https://orcid.org/0000-0002-8137-8392)
- Michelangelo Miccini (ORCID: https://orcid.org/0000-0002-7079-725X)
- F. De Felice
- Michela Roberto (ORCID: https://orcid.org/0000-0001-5339-8348)
- L Archetti
- Daniela Musio (ORCID: https://orcid.org/0000-0003-1373-281X)
- Roberto Caronna (ORCID: https://orcid.org/0000-0002-4683-2756)
- M Mongardini (ORCID: https://orcid.org/0000-0002-2528-827X)
- Franco Iafrate (ORCID: https://orcid.org/0000-0002-6983-8624)
- Giovanni Casella (ORCID: https://orcid.org/0000-0002-1535-7198)
- Elisabetta Merenda (ORCID: https://orcid.org/0000-0002-7231-2295)
- Andrea Picchetto (ORCID: https://orcid.org/0000-0003-4300-9286)
- G. Illuminati
- Ilaria Clementi (ORCID: https://orcid.org/0000-0002-2176-2085)
- Enrico Fiori (ORCID: https://orcid.org/0000-0002-5171-6127)
- Daniele Crocetti (ORCID: https://orcid.org/0000-0001-9950-3553)
- Christian Gentili
- Nadia Bulzonetti
- Giancarlo D’Ambrosio (ORCID: https://orcid.org/0000-0003-2175-3637)
- Enrico Cortesi (ORCID: https://orcid.org/0000-0002-8671-0155)
- Maura Lanzilao
- Elisa Vitti
- Marina Minozzi
- Alessia Delle Donne
- Fabio Massimo Magliocca
Institutions
- Policlinico Umberto I (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Clinical Oncology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1016/j.clon.2024.103698
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00