G-quadruplex stabilizer CX-5461 effectively combines with radiotherapy to target α-thalassemia/mental retardation X-linked-deficient malignant glioma
In totality, our work substantively demonstrates efficacy and defines mechanisms of action for G4 stabilization as a novel therapeutic strategy targeting ATRX-deficient malignant glioma, laying the groundwork for clinical translation.
Authors
- Benjamin T. Whitfield (ORCID: https://orcid.org/0000-0002-2624-8464)
- W. Evan Johnson (ORCID: https://orcid.org/0000-0002-6247-6595)
- Jason T. Huse (ORCID: https://orcid.org/0000-0003-4514-0640)
- Vladislav Sharin
- Ahsan Saleem Farooqi (ORCID: https://orcid.org/0000-0001-9605-7113)
- Christian Alvarez (ORCID: https://orcid.org/0000-0001-7035-657X)
- Sharvari Dharmaiah (ORCID: https://orcid.org/0000-0001-9936-2658)
- Vasudev Tadimeti
- Prit Benny Malgulwar (ORCID: https://orcid.org/0000-0001-9393-1055)
- Brandon Chen (ORCID: https://orcid.org/0009-0003-5241-490X)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1093/neuonc/noae248
- Citations
- 11
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.57